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Document Type |
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Article In Journal |
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Document Title |
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FATTY LIVER IN OVERWEIGHT AND OBESE PATIENTS IN WESTERN PART OF SAUDI ARABIA FATTY LIVER IN OVERWEIGHT AND OBESE PATIENTS IN WESTERN PART OF SAUDI ARABIA |
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Document Language |
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English |
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Abstract |
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Results: - A totalof235 subjects were enrollect'in the study. The mean ageofthe study group was46 +1_ 14:4 years with 82 males (35 %) and 153 fe)tta!es (65%). Mean +/_ SD ilSpartateammo"ansferase level was 43.9+16.18.1units 1L,.alanirieaminotrnsfef6ase was 36.2+1-5.1 units/L. Values of transaminase above the normal range- was present in 15 (6.4%) patients only. Whereas values ofchoIestewI and "iglyceride above normal range was seen in (7:2%) 17 patients. Overweight and obesity were the main riskfaCtors in
ourstudy group. Mean BMl was 33.6+1- 75Xglm2.0besity with diabetes is the most>importantriskforrfatty live •. 78 (33 %) ofountudj< group pa'h,n'",er, mabe'ic; Other riiIefacOO"'",,'ncia'ed withTa'!Y./iver are metabolic syndrome which iST~P9.rtromJ4:9%aflel,nypothyroiOlsm In3:8 %subjects.
Conclusion and'reoommendations:-_
OV\>""elllhtand ooosity Is the most impol'tant tisl< lactoc form"" live' ii'S'UdFAtablaI, is rnore prevalen' In,,,,,noles; ... )Jltrasound,appea;rtmnin""enti,"
l\f6sh~:Id enCotmlge o~ese s:I!i,C(s fore gradual, ",eCgilL",doctlouOO'jjnPli>:vet/re.livet. abnOnnaliti",.
Introduction
The term nonalcoholic fatty liver (NASH) was first used by Dr. LUdwig and colleagues in I 980 to describe a previously recognized c1iniopathologic syndrome I. The original syndrome was described predominantly in obese, diabetic women, who denied alcohol use, but in whom the hepatic histology was consistent with alcoholic hepatitis ?
Nonalcoholic fatty liver disease is now recognized as the most common liver disease in the United States, with a prevalence of approximately 5% in the general population 3 and reaching 25 % to 75% in patients with obesity and type 2 diabetes mellitus 4. A prevalence of 7- I 0% has been reported in the general population of Saudi Arabia 5,6.
Nonalcoholic fatty liver disease covers a spectrum of disease ranging from simple fatty deposition in the liver to inflammation and finally to fibrosis and cirrhosis 7,8. Although the exact etiology is not clear.
It could possibly be part of large metabolic syndrome associated with insulin resistance, diabetes, obesity and hypertension. Patients typically present with a symptomatic serum amintransferase elevation of 2-3 times normap. Symptoms my include fatigue and abdominal pain. . Physical examination my show hepatomegaly 10. The gold standard test for diagnosis is liver biopsy. Although the procedure is effective as a prognostic indicators .but it is invasive and costly tool to diagnose fatty liver ". The imaging modalities most often used to identify hepatic steatosis
include computed tomograpgy and ultrasonography. Hyperechogenic (bright) liver indicates steatosis in ultrasonography 12. No medical treatment has been found to be totally effective 13. Patients who are overweight or obese should be encouraged for gradual weight reduction which has been associated with improvement in liver abnormalities 14. The prevalence of overweight and obesity is increasing in Saudi Arabia amongst Saudi and expatriates especially in females due to a change in dietary habit and sedentary life style. We studied the association of fatty liver diagnosed by ultasonography and obesity in patients presented to King Abdul Aziz university hospital.
Methods
A clinical notes review was performed on all patients undergoing evaluation for fatty liver with obesity over one year period between April 2003 to April 2004 at King Abdul aziz University Hospital. Fatty liver was diagnosed by ultrasonography using an ATL HOI 5000 abdominal probe at 205-3 MHz. Longtiudinal, subcostal, ascending, and oblique scans were preformed. The ultrasonographic criteria of liver, kidney echo discrepancy, Presence of hyperechoic (bright), echo penetration into the deep portion of the liver, and clarity of liver blood vessels structures were used to diagnose fatty liver.
In most patients' medical charts serum level of alanine (ALT) aspartate (AST) transaminases, bilurubin, albumin, cholesterol, triglyceride, LDL,
96 )0",001 of the B.I"~n Medica Society, volume 17, No.2, Ap"12005 |
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ISSN |
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11299401 |
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Journal Name |
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JOURNAL OF THE BAHRAIN MEDICAL SOCIETY(JBMS). |
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Volume |
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17 |
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Issue Number |
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2 |
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Publishing Year |
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1425 AH
2005 AD |
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Article Type |
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Article |
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Added Date |
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Tuesday, January 20, 2009 |
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