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Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
Association of serum apelin concentrations with colon cancer risks in Saudi patients
علاقة تراكيز مصل الأبلين و خطورة الاصابه بسرطان القولون لدى مرضى سعوديين
Subject
:
Biochemistry department
Document Language
:
Arabic
Abstract
:
Apelin, a protein secreted by the adipose tissue and other organs, has a broad array of physiological roles in the human body including angiogenesis. This study is, to our knowledge, the first to report an association between serum apelin concentrations and colon cancer risk. We evaluated the relationship between serum apelin level and colon cancer risk in representative samples of Saudi females and males. In our case-control study, individuals with colon cancer (n=59; age 53.8 ± 11.8 yr; BMI 25.97±5.8 kg/m2) and colonoscopy-negative controls (n=60; age 47.40±14.1 yr; BMI 28.84±6.3 kg/m2) were recruited from King Abdulaziz hospital and Oncology Center (Jeddah) from 2009 to 2011. Serum apelin levels were measured by ELISA technique. Here, we report that serum apelin concentrations in humans exhibit a sexual dimorphism. In the patient group, we observed a significant increased apelin level in the obese males than the non-obese males (P=0.01) and the obese females (P=0.004). On the other hand, the obese and non-obese female patients showed a significant (P=0.04) decrease in apelin level in compation to the obese and non-obese female controls. Regarding the colon cancer stages, the analysis showed an inverse correlation between serum apelin levels and the stages in obese males (r= - 0.673, P= 0.05). In conclusion, serum apelin levels are likely to be associated with increased colon cancer risk in Saudi obese males.
Supervisor
:
Dr. Roydah N. alharithy
Thesis Type
:
Master Thesis
Publishing Year
:
1433 AH
2012 AD
Added Date
:
Tuesday, July 10, 2012
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
وعد عائض العتيبي
Al-Otaibi, Waad Ayed
Researcher
Master
Files
File Name
Type
Description
33904.pdf
pdf
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