Document Details

Document Type : Thesis 
Document Title :
Development of Biosensor Device Based On Functionalized Graphene
تطوير جهاز استشعار حيوي من الجرافين الوظيفي
 
Subject : Faculty of Sciences > physics department 
Document Language : Arabic 
Abstract : The correct and early diagnosis is a critical issue in modern medicine for the evaluation of symptoms. From this regard, there is a real demand for developing novel devices with small size, low cost, high sensitivity for efficient and fast diagnostics of diseases. This dissertation reports a modified recipe to prepare graphene oxide nanoribbon based on the unzipping of multiwall carbon nanotube (MWCNT) by using oxalic acid and potassium permanganate. The produced graphene oxide ribbons were characterized TEM, XRD, XPS and Raman spectroscopy. These measurements depicted that the MWCNTs were efficiently unzipped to graphene oxide ribbons at 700 wt% of KMnO4. The produced graphene oxide nanoribbons were reduced by hydrazine in the presence of β-cyclodextrin and immobilized with cholesterol oxidase and esterase bienzymes by using 1-admantene carboxylic acid as a functional linker. A field effect transistor based on a single functionalized graphene nanoribbon on Si-chip was constructed. The developed device showed a fast and linear response against cholesterol concentration along a wide range from 0.01mM to 25mM with sensitivity of 81.5 A/mM.cm2. It is also showed a high selectivity, reliability and reproducibility. The proposed FET biosensor based on functionalized graphene nanoribbon will open a new avenue to introduce a simple and a highly sensitive cholesterol biosensor into the service life. 
Supervisor : Prof. Waleed E. Mahmou 
Thesis Type : Master Thesis 
Publishing Year : 1437 AH
2016 AD 
Co-Supervisor : Prof. Farag S. AL- Hazmi 
Added Date : Wednesday, January 27, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
غادة هلال الحربيAl-Harbi, Ghada HelalResearcherMaster 

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