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Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
Phytochemical and Biological Studies of Periploca somaliensis
دراسة فيتوكيميائية وبيولوجية لنبات بريبولوكا صومالينسيس
Subject
:
faculty of Pharmacy
Document Language
:
Arabic
Abstract
:
The aim of current study was to isolate and identify major constituents of periploca somaliensis fruits (family Asclepiadaceae) and assess their cytotoxic activity on three different cell lines: MCF-7 (breast cancer), HepG2 (hepatocellular carcinoma), and HCT-116 (colon cancer). Chemical investigation of CHCl3 fraction of P. somaliensis afforded a new scalarane sesterterpene, namely perisomalien A (1), along with lupeol acetate (2), β-amyrin (3), cycloart-23Z-ene-3b,25-diol (4), and β-sitosterol-3-O-β-D-glucopyranoside (5). Their structures were elucidated by extensive spectroscopic methods including 1D (1H and 13C NMR) and 2D NMR (1H-1H COSY, HSQC, HMBC, and NOESY), in addition to comparison with literature data. Compound (4) showed relatively potent cytotoxic activity on MCF-7 with IC50 9.0 µM, compared to remaining compounds that had moderate effects with IC50 ranging from 19-24 µM. it is worthy noted that all compounds were less cytotoxic towards the other cell lines HepG-2 and HCT-166, with compound (4) possessing the lowest IC50 (25.9 and 19.9 µM) on HepG-2 and HCT-166, respectively.
Supervisor
:
Prof. Gamal Abdallah Mohamed Hussein
Thesis Type
:
Master Thesis
Publishing Year
:
1440 AH
2019 AD
Added Date
:
Wednesday, August 21, 2019
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
خديجة عبد القادر جبل
Jabal, Khadijah Abdulqader
Researcher
Master
Files
File Name
Type
Description
44874.pdf
pdf
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