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Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
Preparation and Characterization of Dapoxetine Transdermal Patches Loaded With an Optimized Drug Nanoparticles Formulation
تحضير وتوصيف لصقات جلدية تحتوي على عقار الدابوكسيتين محملة بجزيئات مستمثلة متناهية الصغر من العقار
Subject
:
faculty of Pharmacy
Document Language
:
Arabic
Abstract
:
This study aimed to develop optimized dapoxetine (DPX) polymeric nanoparticles (PNPs) with subsequent loading into a transdermal patch to avoid the hepatic first-pass metabolism and improve DPX bioavailability. Box-Behnken design was utilized to optimize three formulation factors affecting the particle size and entrapment efficiency (EE) from Chitosan (CS)-Alginate (ALG) PNPs prepared by ionotropic gelation method. Solid-state physicochemical characterization was conducted. Scanning electron microscope (SEM) was performed to the optimized PNPs formulation. Three-level factorial design was used to study the effect of two variables, surfactant hydrophilic-lipophilic balance (HLB) and surfactant percent, on DPX cumulative percent released and percent elongation from transdermal patches loaded with DPX-PNPs. Permeation parameters were calculated following ex-vivo permeation study through rat skin. Transport of PNPs, from the optimized patch, across the skin layers were investigated using a fluorescence laser microscope. Results revealed that an optimized PNPs formulation of 415.94 nm size and 37.31% EE was developed. The optimized PNPs formulation exhibited a spherical shape with the almost uniform size distribution. DPX was entrapped in the polymeric matrix. CS and ALG were electrostatically interacting with the studied crosslinking agents to form a polyelectrolyte complex. During PNPs preparation, a change in DPX from crystalline to amorphous state was occurred. Ex-vivo study illustrated a sustained release profile pattern with enhanced DPX permeation from the patch loaded PNPs formulation when compared to that with pure drug. Moreover, the transdermal patch contains PNPs were able to penetrate deeper into skin layers. So, DPX transdermal patch could be considered as a successful drug delivery with better patient compliance for treatment of premature ejaculation.
Supervisor
:
Dr. Bader Mubarak Aljaeid
Thesis Type
:
Master Thesis
Publishing Year
:
1440 AH
2019 AD
Co-Supervisor
:
Dr. Tarek Abdelnapy Ahmed
Added Date
:
Wednesday, August 21, 2019
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
أسماء محمد العي
Alay, Asmaa Mohammed
Researcher
Master
Files
File Name
Type
Description
44896.pdf
pdf
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