Main Page
Deanship
The Dean
Dean's Word
Curriculum Vitae
Contact the Dean
Vision and Mission
Organizational Structure
Vice- Deanship
Vice- Dean
KAU Graduate Studies
Research Services & Courses
Research Services Unit
Important Research for Society
Deanship's Services
FAQs
Research
Staff Directory
Files
Favorite Websites
Deanship Access Map
Graduate Studies Awards
Deanship's Staff
Staff Directory
Files
Researches
Contact us
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
EFFECT OF CURCUMIN ON HEAD AND NECK CANCERS CELLS GROWTH
تأثير الكوركمين على نمو خلايا سرطانات الرأس والرقبة
Subject
:
faculty of science
Document Language
:
Arabic
Abstract
:
Head and neck cancer (HNC) generally stated as a span of malignant neoplasms that originate from soft tissue. HNC is considered the 7th most frequent type of cancers in the world and the 3rd most common cancers in Saudi Arabia. The current chemotherapy and radiotherapy regimes used to treat cancer show adverse side effects. Natural products are generally safe, effective and less expensive substitutes of anticancer chemotherapeutics. Based on the previous studies for its potential therapeutic uses, curcumin is the major active compound of the turmeric plant, may be used as a good natural therapeutic agent in the prevention and treatment of cancer. It has been recently demonstrated that the chemo-preventive activities of curcumin might be due to its ability to increase DNA damage, apoptosis and cell cycle arrest. The present study aimed to investigate the effect of curcumin on the proliferation of HNO97 cells. The cells were cultured and treated with different concentrations of curcumin, and WST-1 assay was carried out for evaluating the IC50 value after 24 h of treatment. We found that curcumin significantly inhibit the growth of HNO97 in a time and dose-dependent manner (IC50=35μM). Flow cytometry data revealed that curcumin did not alter the cell cycle progression of HNO97 cells, but led to apoptosis in a time-dependent manner. Data from comet assay showed that upon treatment of cells with curcumin, the significant DNA damage was found as evident from comet tail. Finally, curcumin treatment suppressed colony formation capacities of HNO97 cells. Overall findings demonstrate that curcumin inhibits the proliferation and induces apoptosis in HNO97 cells. Our study suggests that curcumin can be developed as a natural therapeutic agent for the management of HNC.
Supervisor
:
Dr. Mazin Abdulaziz Zamzami
Thesis Type
:
Master Thesis
Publishing Year
:
1441 AH
2020 AD
Co-Supervisor
:
Dr. Samar Abdullah Damiati
Added Date
:
Thursday, March 12, 2020
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
زهور خلف الله المالكي
Al-Malki, Zuhur Khalaf Allah
Researcher
Master
Files
File Name
Type
Description
46073.pdf
pdf
Back To Researches Page