Main Page
Deanship
The Dean
Dean's Word
Curriculum Vitae
Contact the Dean
Vision and Mission
Organizational Structure
Vice- Deanship
Vice- Dean
KAU Graduate Studies
Research Services & Courses
Research Services Unit
Important Research for Society
Deanship's Services
FAQs
Research
Staff Directory
Files
Favorite Websites
Deanship Access Map
Graduate Studies Awards
Deanship's Staff
Staff Directory
Files
Researches
Contact us
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
The optimal formulation of icariin in the form of a microemulsion and the evaluation of its efficacy to protect the heart from toxicity caused by the administration of doxorubicin in a rat model.
عمل الصيغة المثالية لدواء الآيكارين بصورة مستحلب متناهي الصغر وتقيم مدى فاعليته لحماية القلب من السمية الناجمة عن تعاطي دواء الدوكسوروبيسين في نموذج الجرذان.
Subject
:
faculty of Pharmacy
Document Language
:
Arabic
Abstract
:
Icariin (ICR) is a flavonoid found in plants and possesses cardioprotective, hepatoprotective, anticancer, and anti-inflammatory properties. Even though icariin has been reported to exhibit therapeutic promise in various preclinical and clinical studies, its widespread clinical utility is limited because of low aqueous solubility and low absorption following oral administration. Thus, an enhanced drug delivery system is required to improve therapeutic efficacy and clinical outcomes. Hence, this research aimed to develop and explore icariin nano-emulsions (ICR-NE) for improved cardioprotective action against doxorubicin (Dox)-induced cardiotoxicity. Critical formulation variables, such as globule size and zeta potential of ICR-NE, were studied using a Box–Behnken response surface design. The improved formulation’s globule size and zeta potential were found to be 110.7 nm and −18.45 mV, respectively. Almost 100% transmittance confirmed the minimum nano-size of ICR-NE. Further, thermodynamic stability study showed absence of cracking and phase separation in ICR-NE. Viscosity studies have reported adequate consistency for oral administration. Additionally, an in vitro drug release study showed a sustained release pattern for ICR-NE. The ICR-NE led to significant (p < 0.01) restoration of both serum cardiac and anti-inflammatory markers and cardiac tissue antioxidants compared to the free ICR and Dox-treated groups. As compared to the free ICR and Dox-treated groups, pre-treatment with ICR-NE caused a reduction in the expression of Bax and caspase-3, and hence, mitigated apoptosis-induced cardiotoxicity. Moreover, pretreatment with ICR-NE caused a significant reduction in the heart weight/body weight ratio of histological and fibrotic aberrations toward normal. In conclusion, the current study showed that ICR-NE exhibits a superior cardioprotective effect, possibly due to improved solubility and antioxidant, anti-inflammatory, and anti-apoptotic activities.
Supervisor
:
Dr. Shadab Aki
Thesis Type
:
Master Thesis
Publishing Year
:
1444 AH
2022 AD
Added Date
:
Monday, February 27, 2023
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
هتون عبد الرحمن محروس
Mahrous, Hatoon Abdulrahman
Researcher
Master
Files
File Name
Type
Description
49053.pdf
pdf
Back To Researches Page